The Gut-Brain Connection: How Your Microbiome Affects Mood After 35

Your gut is often called your "second brain" — and for good reason. The enteric nervous system contains over 500 million neurons and produces 95% of your body's serotonin.

The Midlife Microbiome Shift

Research from the University of California shows that hormonal changes during perimenopause significantly alter gut microbiome composition. Declining estrogen reduces the diversity of beneficial bacteria, which can contribute to mood changes, brain fog, and increased anxiety.

What the Science Says

A landmark 2025 study followed 1,800 women aged 35-55 and found that those with greater microbiome diversity reported 40% fewer mood disturbances and 35% less brain fog.

Practical Steps

Your gut health is not just about digestion — it's foundational to your mental health, immune function, and overall vitality in midlife.